Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

¹Department of Ophthalmology, School of Medicine, University of California, Davis 95616.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie

|January 1, 1992

Abstract:

The feasibility of gamma (gamma)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit gamma-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of greater than 10(4) units gamma-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 10(4) units gamma-interferon, another 5 were given 10(6) units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 10(4) units gamma-interferon significantly reduced the severity of detachments, but injections of 10(6) units induced panuveitis.

Related Experiment Videos

Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

Related Concept Videos

[Research advances in immune and metabolic dysregulation in the diagnosis and treatment of acute-on-chronic liver failure].

First Energy-Scan Measurement of e^{+}e^{-}→K^{+}K^{-} around the ψ(2S) Resonance.

First Experimental Constraint on the Scalar Current in the D^{0(+)}→K[over ¯]ℓ^{+}ν_{ℓ} Transition.

Measurements of the Absolute Branching Fraction of the Semileptonic Decay Ξ^{-}→Λe^{-}ν[over ¯]_{e} and the Axial Charge of Ξ^{-}.

First Observation of D^{0(+)}→K[over ¯]ωe^{+}ν_{e} and Determination of the Branching Fraction of K[over ¯]_{1}(1270)→K[over ¯]ω.

First Measurement of the Absolute Branching Fraction of η_{c}→γγ.

Avoidable adverse events in cataract surgery: a national 11-year study of error types, care process patterns, and patient harm.

A four-year retrospective surgical case series examining postoperative complications following Removal of Silicone Oil (ROSO) scored using the Complications of Retinal Detachment Surgery (CORDS) severity classification tool.

Reduced AI-based sex classification performance in clinically unaffected fellow eyes of patients with polypoidal choroidal vasculopathy: comparison with central serous chorioretinopathy and controls.

Eighteen-month real-world outcomes of intravitreal aflibercept 8 mg in treatment-naïve neovascular age-related macular degeneration: a UK single-centre experience.

Inter-eye comparison of corneal stiffness parameters in primary open-angle glaucoma patients with unilateral damage.

Response to anti-VEGF injections for diabetic macular edema among patients on chronic exogenous insulin therapy.

Related Experiment Videos

Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye

Abstract:

Related Concept Videos

Related Articles