Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracellular matrix gene regulation.

Ken Okazaki1, Linda J Sandell

  • 1Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA.

Clinical Orthopaedics and Related Research
|October 14, 2004
PubMed
Summary

Transcription factors regulate extracellular matrix in skeletal tissues. Sox factors promote cartilage gene expression, while others like Runx2 are key for bone development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discordance in bone mineral density between lumbar spine and hip in patients with rheumatoid arthritis: A cross-sectional study.

Osteoporosis and sarcopenia·2026
Same author

Reframing Fixation Strategy in Total Knee Arthroplasty With Tibial Bone Density as a Central Criterion.

JB & JS open access·2026
Same author

Radiolucent lines after robotic-assisted surface-matching kinematically aligned UKA: short-term incidence and lack of association with tibial alignment.

Archives of orthopaedic and trauma surgery·2026
Same author

Impact of postoperative BMI change on patient-reported outcomes following total knee arthroplasty: A retrospective cohort study.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association·2026
Same author

The prevalence of thoracic vertebral fractures identified with the support of Artificial Intelligence-assisted diagnostic methods in patients hospitalized due to internal medicine diseases.

Internal medicine (Tokyo, Japan)·2026
Same author

Cement mantle thickness in total knee arthroplasty more closely associated with tibial bone density than cement viscosity : findings from a randomized controlled trial.

Bone & joint open·2026

Area of Science:

  • Orthopaedic research
  • Molecular biology
  • Skeletal tissue development

Background:

  • Extracellular matrix (ECM) metabolism is crucial for skeletal tissue development and repair.
  • Gene expression patterns dictate ECM composition in bone and cartilage.
  • Transcription factors are key regulators of ECM gene expression.

Purpose of the Study:

  • To elucidate the roles of specific transcription factors in regulating ECM metabolism in skeletal tissues.
  • To understand the balance of positive and negative regulators in chondrogenesis and osteogenesis.

Main Methods:

  • Analysis of gene expression patterns in skeletal tissues.
  • Identification of key transcription factors involved in ECM regulation.
  • Review of existing literature on transcription factor function in cartilage and bone.

Related Experiment Videos

Main Results:

  • Sox transcription factors are critical positive regulators of cartilage-specific genes (e.g., COL2A1, aggrecan).
  • Negative regulators (e.g., snail/slug, C/EBP) fine-tune gene expression in chondrocytes.
  • Runx2 and osterix are essential for osteogenesis and influence chondrogenesis.

Conclusions:

  • A precise balance of transcription factors is essential for proper skeletal development and ECM homeostasis.
  • Understanding these regulatory mechanisms can inform treatments for orthopaedic diseases and injuries.