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Related Experiment Videos

Presymptomatic spondylotic cervical cord compression.

Josef Bednarik1, Zdenek Kadanka, Ladislav Dusek

  • 1Department of Neurology, University Hospital, Brno, Czech Republic. jbednar@fnbrno.cz

Spine
|October 14, 2004
PubMed
Summary

Early detection of cervical myelopathy is possible. Electrophysiological abnormalities and cervical radiculopathy symptoms can predict progression in asymptomatic spinal cord compression patients.

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Area of Science:

  • Neurology
  • Spinal Cord Imaging
  • Clinical Prediction Models

Background:

  • Controversial data exists on predicting outcomes for spondylotic cervical myelopathy.
  • The natural history of asymptomatic cervical cord compression is poorly understood.

Purpose of the Study:

  • To identify predictors of progression from asymptomatic to symptomatic cervical myelopathy.
  • Investigate demographic, clinical, imaging, and electrophysiological factors.

Main Methods:

  • Prospective cohort study of 66 asymptomatic patients with magnetic resonance imaging (MRI)-detected cervical cord compression.
  • Follow-up for at least 2 years, correlating various parameters with clinical outcomes.

Main Results:

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  • 19.7% of patients developed symptomatic cervical myelopathy.
  • Predictive factors included symptomatic cervical radiculopathy, anterior horn lesions on electromyography, and abnormal somatosensory-evoked potentials.
  • A multivariate model achieved 90% classification accuracy.

    • Conclusions:

    • Electrophysiological abnormalities and cervical radiculopathy predict symptomatic progression.
    • Enables identification of high-risk individuals with preclinical spondylotic cervical cord compression.