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Cadaveric allograft microbiology.

T Ibrahim1, H Stafford, C N A Esler

  • 1Department of Orthopaedic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK. talal_ibrahim@hotmail.com

International Orthopaedics
|October 14, 2004
PubMed
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This study found significant contamination rates in cadaveric bone allografts (27%) and blood cultures (37%). Most contaminants were skin bacteria, with rare instances of pathogens like Clostridium.

Area of Science:

  • Medical Microbiology
  • Tissue Banking
  • Infectious Disease

Background:

  • Cadaveric bone allografts are crucial in reconstructive surgery.
  • Understanding contamination rates in allograft procurement is vital for patient safety.
  • Previous studies have indicated varying contamination levels in biological tissues.

Purpose of the Study:

  • To determine the contamination rates of cadaveric bone allografts and associated blood cultures.
  • To identify common microorganisms present in contaminated allografts and blood samples.
  • To assess the impact of the post-mortem interval on blood culture contamination.

Main Methods:

  • Retrospective analysis of 119 donors from Leicester (1990-2003).
  • Culturing of 437 bone allografts and 107 blood samples.

Related Experiment Videos

  • Microbiological identification of all positive cultures.

    • Main Results:

    • A 27% contamination rate was observed in bone allografts (120/437).
    • A 37% contamination rate was found in blood cultures (40/107).
    • Coagulase-negative Staphylococcus was the most frequent isolate; Clostridium was identified in one blood culture.

    Conclusions:

    • Cadaveric bone allografts and blood cultures exhibit substantial contamination rates.
    • The primary contaminants are typically skin commensals, posing a low risk of severe infection.
    • The time between death and procurement did not significantly affect blood culture contamination rates.