Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growing new kidneys in situ.

Marc R Hammerman1

  • 1Renal Division, Box 8126, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. mhammerm@im.wustl.edu.

Clinical and Experimental Nephrology
|October 14, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation and use of renal cells for replacement therapies.

Current opinion in organ transplantation·2015
Same author

Underpinnings of cellular organ replacement therapies.

Current opinion in organ transplantation·2014
Same author

Classic and current opinion in embryonic organ transplantation.

Current opinion in organ transplantation·2014
Same author

Xenotransplantation of embryonic pig pancreas for treatment of diabetes mellitus in non-human primates.

Journal of biomedical science and engineering·2013
Same author

Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear (1) H/(19) F MRI and perfluorocarbon nanoparticles.

Magnetic resonance in medicine·2013
Same author

Development of a novel xenotransplantation strategy for treatment of diabetes mellitus in rat hosts and translation to non-human primates.

Organogenesis·2012

Growing new organs for transplantation is possible by transplanting animal kidney primordia. These develop into functional kidneys within the host, offering a potential solution to organ shortages.

Area of Science:

  • Regenerative Medicine
  • Xenotransplantation
  • Developmental Biology

Background:

  • Human organ shortages for transplantation are a significant clinical challenge.
  • Xenotransplantation of developing organs offers a novel therapeutic strategy.
  • Renal primordia (metanephroi) can be utilized for in situ organogenesis.

Purpose of the Study:

  • To review the therapeutic potential of renal primordia transplantation for organogenesis.
  • To explore the feasibility of using xenotransplantation for kidney development.
  • To assess the viability of metanephroi for regenerative purposes.

Main Methods:

  • Transplantation of metanephroi into host animals for in situ development.
  • Assessment of vascularization by host blood vessels.

Related Experiment Videos

  • Evaluation of excretory function post-transplantation.
  • In vitro storage and transplantation across xenogeneic barriers (rat-to-mouse, pig-to-rodent).

    • Main Results:

    • Metanephroi undergo successful organogenesis in situ after transplantation.
    • Transplanted kidneys become vascularized by host vasculature.
    • Excretory function is established in the developing organs.
    • Successful xenotransplantation across various species barriers has been demonstrated.

    Conclusions:

    • In situ renal organogenesis via metanephroi xenotransplantation shows therapeutic promise.
    • This approach could address the critical shortage of transplantable human organs.
    • Further research into xenotransplantation of kidney primordia is warranted.