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Bisalbuminemia in chronic kidney disease
A Ahsan Ejaz1, Murli Krishna, Andrew Wasiluk
1Division of Nephrology and Hypertension, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Clinical and Experimental Nephrology
|October 14, 2004
Summary
Bisalbuminemia, a rare condition with altered albumin in the blood, was incidentally found in a patient with chronic kidney disease. This finding did not impact the patient's diagnosis or treatment outcomes.
Area of Science:
- Clinical Biochemistry
- Nephrology
Background:
- Bisalbuminemia is a rare condition characterized by the presence of an albumin variant in serum, differing from normal albumin A by single amino-acid substitutions.
- This condition has been observed across various ethnic groups and in association with diverse pathological states, though its significance in disease pathophysiology remains unclear.
Observation:
- A 68-year-old woman with chronic kidney disease (CKD) presented with an unexplained worsening of serum creatinine levels.
- Serum protein electrophoresis revealed bisalbuminemia as an incidental finding.
- The patient's renal function stabilized following dietary protein restriction and antihypertensive therapy.
Findings:
- Bisalbuminemia was identified incidentally during routine serum protein electrophoresis in a patient with CKD.
- The presence of bisalbuminemia did not alter the diagnostic approach, management strategy, clinical course, or prognosis of the patient's chronic kidney disease.
- Serum creatinine levels improved with standard CKD management interventions.
Implications:
- The study suggests that incidental bisalbuminemia may not significantly influence the management or outcome of chronic kidney disease.
- Further research is needed to elucidate the precise role, if any, of persistent bisalbuminemia in the context of renal disease.
- The potential impact of albumin variants on the binding of physiological or pharmacological substances warrants consideration in specific clinical scenarios.