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Updated: Aug 21, 2026

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Published on: January 6, 2023
Permanent cardiac pacing as primary therapy for neurocardiogenic (reflex) syncope
Daniel J Kosinski1, Blair P Grubb, Douglas A Wolfe
1Electrophysiology Section, Division of Cardiology, Dept. of Medicine, Medical College of Ohio, Toledo, OH 43614, USA.
Abstract:
Recurrent reflex (or neurocardiogenic) syncope is a common clinical problem. Pacemaker therapy has been advocated as a potential therapy in severe or drug refractory cases of reflex syncope, while others have suggested that it may provide a benefit if employed as a primary therapeutic modality. The following paper reviews the concepts behind pacemaker therapy for reflex syncope and the results of various clinical trials that have evaluated its potential utility as a primary therapeutic modality.
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