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Low biological activity of Helicobacter pylori lipopolysaccharide
A Muotiala1, I M Helander, L Pyhälä
1Department of Bacteriology, National Public Health Institute, Helsinki, Finland.
Infection and Immunity
|April 1, 1992
Abstract:
Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.