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Clinical evaluation of the peak inspiratory flow generated by asthmatic children through the Novolizer

C Vogelberg1, H J Kremer, B Ellers-Lenz

  • 1Department of Paediatrics, University of Dresden, Fetscherstr 74, Dresden 01307, Germany. christian.vogelberg@uniklinikum-dresden.de

Respiratory Medicine
|October 16, 2004
PubMed

Insights

Asthmatic children can generate adequate peak inspiratory flow (PIF) using the Novolizer dry powder inhaler. This novel device, with its feedback features, is suitable for delivering asthma medications effectively.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Device Technology

Background:

  • Asthma management in children requires effective medication delivery.
  • Dry powder inhalers (DPIs) necessitate sufficient inspiratory flow for optimal function.

Purpose of the Study:

  • To evaluate if children with asthma can achieve adequate peak inspiratory flow (PIF) through the Novolizer DPI.
  • To assess the Novolizer's suitability for pediatric inhalation therapy.

Main Methods:

  • A multi-center study involving 137 children (median age 7 years) with mild to moderate persistent asthma.
  • Peak inspiratory flow (PIF) was measured without the device and then through the Novolizer (PIF-N).
  • Assessments were performed in triplicate, with the mean analyzed.

Main Results:

  • Mean PIF was 128 ± 61 L/min, and mean PIF-N was 69 ± 18 L/min.
  • These flow rates exceed the Novolizer's required trigger threshold.
  • PIF through the Novolizer showed a linear increase from ages 4-8 years.

Conclusions:

  • The Novolizer's low intrinsic resistance allows for high PIF in children.
  • Acoustic and optical feedback mechanisms enhance correct inhalation technique.
  • The Novolizer is a valuable tool for delivering inhaled corticosteroids and bronchodilators to asthmatic children.
Abstract

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