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Indeterminate cell histiocytosis: a case report.

Chun-Hua Wang1, Gwo-Shing Chen

  • 1Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

The Kaohsiung Journal of Medical Sciences
|October 16, 2004
PubMed
Summary

Indeterminate cell histiocytosis is a rare skin neoplasm. This case highlights a favorable response to psoralen ultraviolet A-range treatment in a patient with this condition.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Indeterminate cell histiocytosis (ICH) is a rare neoplastic proliferation of histiocytes.
  • ICH cells exhibit mixed features of Langerhans cells and non-Langerhans cells.

Observation:

  • A 36-year-old woman presented with asymptomatic generalized papules and nodules on extremities, trunk, and cheeks.
  • Lesions were firm, painless, non-pruritic, flesh-yellow to reddish-brown, developing over 6 months.

Findings:

  • Histopathology revealed diffuse dermal histiocytic infiltration without atypia or epidermotropism.
  • Immunohistochemistry showed neoplastic cells expressing Langerhans cell markers (CD1a, S-100) and monocyte/macrophage markers (Factor XIIIa, CD68).
  • Electron microscopy did not identify Birbeck granules; flow cytometry showed increased CD34+ cells.

Implications:

  • This case demonstrates a positive response to psoralen ultraviolet A-range (PUVA) therapy for indeterminate cell histiocytosis.
  • Presents a rare case of ICH with specific immunophenotypic findings.
  • Contributes to the literature on ICH management and characteristics.

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