Related Experiment Video
Updated: Aug 9, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Post-challenge hyperglycaemia rather than fasting hyperglycaemia is an independent risk factor of cardiovascular
Weiguo Gao1, Qing Qiao, Jaakko Tuomilehto
1Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland. gao.weiguo@ktl.fi
Abstract:
Evidence accumulated from several large-scale epidemiological and intervention studies strongly indicates that hyperglycaemia and specifically post-challenge hyperglycaemia is an independent factor related to the increased risks of cardiovascular disease. The DECODE (Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe) study has de-emphasized the importance of fasting glucose, in contrast to post-challenge hyperglycaemia, as the principal measurable determinant of glycaemic exposure contributing to the risk of cardiovascular disease in Type 2 diabetes and even in non-diabetic subjects. The study, based on five Finnish DECODE study cohorts, demonstrated that in subjects without previous myocardial infarction, 2-h post-challenge glucose after an oral glucose tolerance test was a stronger predictor of the risk of serious coronary heart disease events than fasting glucose. Post-challenge hyperglycaemia was identified as an independent risk factor for cardiovascular disease also in Cardiovascular Health Study and the Framingham Offspring Study. It seems fair to conclude that post-challenge glucose is likely to be an independent cardiovascular risk factor. The mechanism for the increased risk in the incidence and mortality related to post-challenge hyperglycaemia has been speculated. To recognize that post-challenge hyperglycaemia is an important risk factor for cardiovascular disease may be of a significant preventive importance.
More Related Videos
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Hypoglycemia and Glucagon
Type II Diabetes I: Introduction
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Hypoglycemia
Hyperglycemia