Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence for a major gene influence on persistent developmental stuttering.

Nagalapura Viswanath1, Hee Suk Lee, Ranajit Chakraborty

  • 1Stuttering Center Speech Motor and Control Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

Human Biology
|October 16, 2004
PubMed
Summary

Genetic factors significantly influence persistent developmental stuttering. Analysis suggests an autosomal dominant gene, with sex and parental status as key factors, guiding future genetic research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry.

BMC cancer·2020
Same author

Differentiation of Hispanic biogeographic ancestry with 80 ancestry informative markers.

Scientific reports·2020
Same author

Facial clefting and Amerindian admixture in populations of Santiago, Chile.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

BOTTLENECK EFFECTS ON AVERAGE HETEROZYGOSITY AND GENETIC DISTANCE WITH THE STEPWISE MUTATION MODEL.

Evolution; international journal of organic evolution·2017
Same author

THE BOTTLENECK EFFECT AND GENETIC VARIABILITY IN POPULATIONS.

Evolution; international journal of organic evolution·2017
Same author

CORRELATIONS BETWEEN SOME MEASURES OF GENETIC DISTANCE.

Evolution; international journal of organic evolution·2017

Area of Science:

  • Genetics
  • Speech and Language Disorders
  • Human Biology

Background:

  • Stuttering is a complex developmental speech disorder with unknown causes.
  • Family studies indicate a genetic component, but the transmission pattern remains unclear.
  • Previous research showed a 10-fold higher risk for relatives of persistent developmental stutterers.

Purpose of the Study:

  • To conduct a complex segregation analysis on existing family data for persistent developmental stuttering.
  • To identify the genetic model best explaining stuttering inheritance.
  • To inform future genomewide linkage studies.

Main Methods:

  • Utilized logistic regression models from SAGE software for segregation analysis.
  • Compared likelihoods of various genetic and non-genetic models.

Related Experiment Videos

  • Applied a refined Mendelian model to 47 informative multiplex pedigrees.

    • Main Results:

    • A Mendelian model was superior to non-genetic and general transmission models.
    • The most parsimonious model indicated an autosomal dominant major gene effect.
    • Sex and parental affection status were identified as significant covariates.
    • Linkage simulation predicted an average lod score of 6.8 for genome scan markers.

    Conclusions:

    • Evidence supports a major autosomal dominant gene influencing stuttering susceptibility.
    • The findings provide a strong basis for genomewide linkage analysis.
    • Understanding the genetic architecture of stuttering is crucial for developing targeted interventions.