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Spontaneous renal allograft rupture without acute rejection
Nicola Busi1, Enzo Capocasale, Maria Patrizia Mazzoni
1Department of Surgery, Institute of General Surgery and Organ Transplantation, University of Parma, Italy. busi@nemo.unipr.it
Acta Bio-Medica : Atenei Parmensis
|October 16, 2004
Summary
Renal allograft rupture (RAR), a rare kidney transplant complication, can occur without acute rejection. Severe acute tubular necrosis and renal vein thrombosis were identified as potential causes in four cases.
Area of Science:
- Nephrology
- Transplant Surgery
Background:
- Renal allograft rupture (RAR) is a rare but serious complication following kidney transplantation.
- Acute rejection is the most common cause of RAR.
Observation:
- This study reports four cases (0.5%) of RAR in 778 kidney transplants.
- These cases were attributed to severe acute tubular necrosis and renal vein thrombosis, with no evidence of acute rejection.
Findings:
- Renal allograft rupture can occur in the absence of acute rejection.
- Severe acute tubular necrosis and renal vein thrombosis are potential causes of RAR.
Implications:
- Transplant nephrectomy is often required for RAR.
- Conservative surgical management should be considered to preserve the allograft in select cases.