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Updated: Aug 21, 2026

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
Published on: January 13, 2023
The response of human natural killer cells to interleukin-2
P Mirandola1, C Ponti, G Gobbi
1Department of Anatomy, Pharmacology and Forensic Medicine, University of Parma, Ospedale Maggiore, Parma, Italy.
Abstract:
Natural killer cells play a key role in the defence of organisms against virus infections and in the control of tumor onset. Interleukin-2 is a multifunctional inflammatory cytokine able to activate natural killer cells, essentially inducing cell proliferation, lymphokine-activated-killer cell generation and cytokine production. Here we discuss some signaling events generated by interleukin-2 in the cell nucleus of primary human natural killer cells, specifically focusing on the lipid signal transduction and the induction of the cyclic adenosine-5'-monophosphate response element binding protein transcription factor. The implications of these nuclear events in the response of natural killer cells to interleukin-2 are also discussed.
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