Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria
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Updated: Feb 8, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
S Ehrhardt1, D Wichmann, C J Hemmer
1Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. ehrhardt@bni-hamburg.de
Abstract:
In an unmatched case-control study of 63 non-immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (H-FABP), myoglobin, troponin T and creatin kinase-muscle brain were compared. Elevated levels of NT-proBNP and H-FABP indicated myocardial impairment in complicated but not in uncomplicated falciparum malaria. The clinical impact of these findings remains to be evaluated. The pathophysiology of cardiac impairment in complicated falciparum malaria warrants further investigation.
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