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Assisted reproductive techniques in patients with Klinefelter syndrome: a critical review
Dominik Denschlag1, Clemens Tempfer, Myriam Kunze
1Department of Obstetrics and GynecologyUniversity of Freiburg, Freiburg, Germany. ddensch@frk.ukl.uni-freiburg.de
Objective:
To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients.
Design:
A systematic review of the literature, including all published case reports to date.
Patient(S):
Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.
Main Outcome Measure(S):
The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients.
Result(S):
In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI.
Conclusion(S):
The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.
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