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Protein Z levels and unexplained fetal losses

Elvira Grandone1, Donatella Colaizzo, Filomena Cappucci

  • 1Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (Foggia) and Medical Genetics, University of Foggia, Foggia, Italy. grandone@katamail.com

Fertility and Sterility
|October 16, 2004
PubMed

We evaluated protein Z plasma levels in a group of women with fetal losses (n = 124) and compared them with those in a group of women (n = 60) with uneventful pregnancies. We found that protein Z deficiency is not associated with otherwise unexplained fetal losses.

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...