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Updated: Aug 21, 2026

Valorization of the Red Seaweed Gracilaria gracilis Through a Biorefinery Approach
Published on: November 21, 2023
Quantitative structure-activity relationship analyses of antioxidant and free radical scavenging activities for
Chisako Yamagami1, Noriko Motohashi, Tatsuhiko Emoto
1Kobe Pharmaceutical University, Motoyamakita-machi, Higashinadaku, Kobe 658-8558, Japan. yamagami@kobepharma-u.ac.jp
Abstract:
Antioxidant activities for a series of hydroxybenzalacetones, OH-BZ, were evaluated by measuring inhibitory potencies of OH-BZ against lipid peroxidation induced by t-BuOOH or gamma-irradiation. Their quantitative structure-activity relationship (QSAR) studies indicated that the activities are mainly governed by electronic and steric factors. To rationalize these results, we also performed QSAR analyses for DPPH radical scavenging activities of OH-BZ, which indicated that antioxidant and radical scavenging activities could be expressed by the same physicochemical parameters but the hydrogen bonding behavior of phenolic OH varies with the reaction medium.
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