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beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis
Ele Ferrannini1, Amalia Gastaldelli, Yoshinori Miyazaki
1Diabetes Division, Department of Internal Medicine, University of Texas Health Science Center, San Antonio 78229-3900, USA. ferranni@ifc.cnr.it
The Journal of Clinical Endocrinology and Metabolism
|October 16, 2004
Abstract:
The nature of the progressive beta-cell failure occurring as normal glucose tolerant (NGT) individuals progress to type 2 diabetes (T2DM) is incompletely understood. We measured insulin sensitivity (by a euglycemic insulin clamp) and insulin secretion rate (by deconvolution of plasma C-peptide levels during an oral glucose tolerance test) in 188 subjects [19 lean NGT (body mass index [BMI]