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Related Experiment Videos

Astroblastoma: a case report.

Dong Sug Kim1, So Yoon Park, Sang Pyung Lee

  • 1Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. dskim@yumail.ac.kr

Journal of Korean Medical Science
|October 16, 2004
PubMed
Summary
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Astroblastoma, a rare brain tumor in young individuals, presents with characteristic perivascular pseudorosettes. This case highlights a large astroblastoma in a 15-year-old girl, emphasizing typical histological and immunohistochemical features.

Area of Science:

  • Neuro-oncology
  • Pediatric Pathology

Background:

  • Astroblastoma is a rare and poorly understood primary brain tumor, predominantly affecting children and young adults.
  • Its histogenesis remains unclear, making diagnosis and treatment challenging.

Observation:

  • A 15-year-old female presented with a year-long history of headache and diplopia.
  • Brain MRI revealed a large (9.7 cm), well-demarcated, inhomogenous, and well-enhanced mass in the right frontal lobe.
  • The tumor exhibited cystic changes but lacked peritumoral edema.

Findings:

  • Histopathological examination confirmed a typical astroblastoma, with no features of anaplastic astrocytoma, gemistocytic astrocytoma, or glioblastoma.
  • Characteristic perivascular pseudorosettes with vascular hyalinization were noted.

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  • Immunohistochemistry showed diffuse positivity for GFAP, S-100, vimentin, and NSE, with focal positivity for EMA and CAM 5.2, and negativity for neuroblastic markers.

    • Implications:

    • This case contributes to the understanding of astroblastoma presentation and histology in a young patient.
    • Accurate diagnosis through histology and immunohistochemistry is crucial for differentiating astroblastoma from other glial tumors.
    • Further research into astroblastoma histogenesis and behavior is warranted.