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Updated: Aug 21, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
Understanding carbohydrate-carbohydrate interactions by means of glyconanotechnology
Jesus M de la Fuente1, Soledad Penadés
1Grupo Carbohidratos, Laboratory of Glyconanotechnology IIQ-CSIC, Américo Vespucio s/n, 41092 Sevilla, Spain.
Abstract:
Carbohydrate-carbohydrate interaction is a reliable and versatile mechanism for cell adhesion and recognition. Glycosphingolipid (GSL) clusters at the cell membrane are mainly involved in this interaction. To investigate carbohydrate-carbohydrate interaction an integrated strategy (Glyconanotechnology) was developed. This strategy includes polyvalent tools (gold glyconanoparticles) mimicking GSL clustering at the cell membrane as well as analytical techniques such as AFM, TEM, and SPR to evaluate the interactions. The results obtained by means of this strategy and current status are presented.
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