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Candida glabrata periprosthetic infection: a case report and literature review

Glenn Gaston1, John Ogden

  • 1Atlanta Medical Center, Georgia, USA.

The Journal of Arthroplasty
|October 16, 2004
PubMed

We present a case of an immunocompromised host who developed a Candida glabrata infection 20 years after her total knee arthroplasty. She was treated with extensive irrigation and debridement, followed by placement of an amphotericin B cement spacer supplemented with 2 months of oral variconazole. She ultimately underwent an above-knee amputation.

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Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...