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Opisthorchiasis-associated biliary stones: light and scanning electron microscopic study
Banchob Sripa1, Pipatphong Kanla, Poonsiri Sinawat
1Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. banchob@kku.ac.th
World Journal of Gastroenterology
|October 16, 2004
Summary
Opisthorchis viverrini (liver fluke) infestation is linked to pigment gallstones in Thailand. This study found parasite eggs in bile and stones, suggesting a role in their formation.
Area of Science:
- Gastroenterology
- Hepatology
- Parasitology
Background:
- Biliary stones are common in opisthorchiasis-endemic regions of Thailand.
- The specific prevalence and pathogenesis of these stones require further elucidation.
Purpose of the Study:
- To determine the prevalence of biliary stones in patients undergoing cholecystectomy in Thailand.
- To investigate the role of Opisthorchis viverrini infestation in the pathogenesis of these stones.
Main Methods:
- Analysis of gallstones and bile from 113 cholecystectomies.
- Examination of bile for Opisthorchis viverrini eggs, calcium, and bilirubin.
- Scanning electron microscopy (SEM) of stones to identify parasite eggs and crystal morphology.
Main Results:
- Pigment stones were prevalent (82/113 cases), with only one cholesterol stone case.
- Opisthorchis viverrini eggs were found in 50% of bile samples.
- SEM confirmed parasite eggs within stones, alongside calcium bilirubinate and cholesterol precipitates.
Conclusions:
- Northeast Thailand exhibits a high prevalence of pigment gallstones.
- Opisthorchis viverrini infestation is implicated in the pathogenesis of pigment gallstone formation.