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Autoantibodies associated with reproductive failure
1Internal Medicine B and The Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel. shoenfel@post.tau.ac.il
Lupus
|October 16, 2004
Summary
Autoimmune factors, including various autoantibodies, are linked to reproductive failure in women, particularly those with systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS). Further research is needed to identify all relevant autoantibodies for improved diagnosis and treatment.
Area of Science:
- Reproductive immunology
- Clinical immunology
- Autoimmunity
Background:
- Reproductive failure affects numerous women, with autoimmune factors playing a significant role in some cases.
- Autoimmune conditions like systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are frequently associated with reproductive challenges.
Purpose of the Study:
- To review and summarize the known autoantibodies implicated in reproductive failure.
- To highlight autoantibodies found in patients with SLE or APS experiencing reproductive failure.
- To identify autoantibodies requiring further investigation for their association with reproductive failure.
Main Methods:
- Literature review of studies investigating autoantibodies in reproductive failure.
- Analysis of autoantibodies identified in patients diagnosed with SLE or APS and reproductive failure.
- Identification of autoantibodies with potential, but unconfirmed, links to reproductive failure.
Main Results:
- Key autoantibodies include those targeting phospholipids (e.g., cardiolipin, phosphatidylserine) and phospholipid-binding glycoproteins (e.g., beta2glycoprotein-I, annexin V).
- Other identified autoantibodies in SLE/APS patients with reproductive failure include anti-laminin-I, anti-thromboplastin, and anti-thyroglobulin antibodies.
- Autoantibodies against actin, enolase, and cubilin are noted, but their association with reproductive failure requires more research.
Conclusions:
- Autoantibodies are significant contributors to reproductive failure, especially in the context of SLE and APS.
- A comprehensive panel of autoantibodies should be screened in patients with reproductive failure.
- Future research, potentially utilizing proteomics, will expand the understanding of autoantibody specificities and their clinical relevance in reproductive failure.