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European register of babies born to mothers with antiphospholipid syndrome

M C Boffa1, M H Aurousseau, E Lachassinne

  • 1Department of Internal Medicine, Hôpital de la Pitié, Paris, France. marie-claire.boffa@psl.ap-hop-paris.fr

Lupus
|October 16, 2004
PubMed

Insights

This study tracks infants born to mothers with antiphospholipid syndrome (APS). It monitors infant health and neurodevelopment up to five years, providing crucial data on APL antibody effects.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Immunology

Background:

  • Antiphospholipid syndrome (APS) in pregnant mothers poses risks to fetal outcomes.
  • Long-term effects of maternal APS on infant neurodevelopment require further investigation.
  • Understanding the impact of antiphospholipid antibodies (APL) on infants is critical for clinical management.

Purpose of the Study:

  • To investigate the clinical and immunological status of infants born to mothers with APS.
  • To follow the neurodevelopmental outcomes of these infants up to five years of age.
  • To analyze the kinetics of antiphospholipid antibodies in infants born with APL.

Main Methods:

  • Prospective, multicentric register initiated by the European Forum of Antiphospholipid Antibodies (APL).
  • Informed parental consent obtained for infant investigation.
  • Collection of maternal APS clinical data, pregnancy outcomes, and immunological status.
  • Clinical and immunological examinations of infants at birth.
  • Neurodevelopmental follow-up of infants for up to five years.
  • Kinetics of lupus anticoagulant (LA) and anticardiolipin (ACL) antibodies monitored if positive at birth.

Main Results:

  • Data collection on maternal APS, pregnancy course, and infant health is ongoing.
  • Infant clinical and immunological status at birth is being recorded.
  • Neurodevelopmental assessments are being performed up to five years post-birth.
  • Kinetics of APL antibodies in infants will be analyzed.
  • A descriptive and case-control study will be enabled upon reaching 300 cases.

Conclusions:

  • The register provides a unique dataset for understanding the impact of maternal APS on infant health.
  • Longitudinal data on infant neurodevelopment will offer insights into potential long-term effects.
  • Analysis of APL antibody kinetics may reveal important immunological patterns in exposed infants.

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