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Updated: Aug 17, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
Published on: August 8, 2014
Albumin-like material in urine
Wayne D Comper1, Tanya M Osicka
1Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. wcomper@ausambiotech.com
Abstract:
Recent studies have demonstrated the presence, in both rat and human urine, of a modified form of albumin not detected by conventional antibodies. This modified albumin behaves physicochemically as intact albumin under nondenaturing conditions. We have demonstrated this form of albumin to be disproportionately excreted in microalbuminuric states in diabetes. Quantitation of this modified form of albumin leads to the prediction of the onset of microalbuminuria in diabetic patients on average 3 to 4 years earlier than when measured by conventional immunoassays.
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