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Related Experiment Videos

Acne treated successfully with azithromycin.

Naseema Kapadia1, Abu Talib

  • 1Karachi Medical and Dental College/Abassi Shaheed Hospital, Aga Khan University Hospital, Dow Medical College, Karachi, Pakistan. naseemakapadia@yahoo.com

International Journal of Dermatology
|October 16, 2004
PubMed
Summary

Azithromycin, 500 mg thrice weekly for 12 weeks, effectively treated acne vulgaris, showing significant lesion reduction and excellent patient compliance. This macrolide antibiotic offers a safe therapeutic option for managing acne vulgaris.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Acne vulgaris is a common inflammatory skin condition affecting adolescents and adults.
  • Effective management of acne vulgaris requires treatments that address inflammation and bacterial factors.

Purpose of the Study:

  • To evaluate the efficacy, safety, and patient compliance of azithromycin (500 mg) administered thrice weekly for 12 weeks in treating acne vulgaris.

Main Methods:

  • An open-label, noncomparative study involved 35 patients with moderate to severe papulopustular acne vulgaris.
  • Participants received oral azithromycin 500 mg thrice weekly for 12 weeks.
  • Efficacy was assessed by lesion clearance, safety by adverse events, and compliance at regular intervals.

Main Results:

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  • 82.9% of patients showed significant improvement within 4 weeks, with an 80% reduction in inflammatory lesions by 12 weeks.
  • Four patients (11.4%) reported mild adverse events (heartburn, nausea).
  • All participants completed the 12-week treatment, indicating high compliance.
  • Conclusions:

    • Azithromycin 500 mg thrice weekly is a safe and effective treatment for acne vulgaris.
    • The regimen demonstrated excellent patient compliance and significant clinical improvement.
    • Further research may explore long-term efficacy and management of scarring post-treatment.