Related Experiment Video

Updated: Aug 21, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism

Berthold Hoppe1, Farzaneh Tolou, Hartmut Radtke

  • 1Institutee of Transfusion Meidicine, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. berthold.hoppe@charite.de

Blood
|October 16, 2004
PubMed

Insights

The factor VII-activating protease (FSAP) Marburg I variant is linked to an increased risk of venous thromboembolism (VTE). This finding suggests FSAP Marburg I may be an independent risk factor for VTE occurrence, especially in idiopathic cases.

Area of Science:

  • Vascular Biology
  • Hemostasis and Thrombosis
  • Genetic Risk Factors

Background:

  • The factor VII-activating protease (FSAP) Marburg I variant is known to affect the profibrinolytic system.
  • Previous research indicated FSAP Marburg I predicts carotid stenosis progression.

Purpose of the Study:

  • To investigate the association between the FSAP Marburg I variant and the risk of developing venous thromboembolism (VTE).

Main Methods:

  • A case-control study design was employed.
  • The frequency of the FSAP Marburg I variant was compared between patients with VTE and healthy controls.
  • Logistic regression analysis was used to determine independent risk factors.

Main Results:

  • FSAP Marburg I was significantly more frequent in patients with a history of VTE (8.0%) and idiopathic VTE (11.7%) compared to controls (2.3%).
  • Logistic regression confirmed FSAP Marburg I as an independent risk factor for VTE (OR, 3.5) and idiopathic VTE (OR, 6.2).

Conclusions:

  • The FSAP Marburg I variant is associated with an increased risk of venous thromboembolism.
  • FSAP Marburg I may serve as a significant independent risk factor for VTE, particularly for idiopathic VTE.

More Related Videos

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...