Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin-dependent diabetes and gut dysfunction: the BB rat model.

W J Malaisse1, P Courtois, F W Scott

  • 1Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium. malaisse@ulb.ac.be.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|October 16, 2004
PubMed
Summary

Diet significantly impacts type 1 diabetes development in BB rats by affecting gut health. Specific dietary components and gut immune system changes are linked to diabetes incidence in this animal model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Realization of an advanced super-mirror solid-state neutron polarizer for the instrument PF1B at the Institut Laue-Langevin.

The Review of scientific instruments·2023
Same author

Dysregulated liver lipid metabolism and innate immunity associated with hepatic steatosis in neonatal BBdp rats and NOD mice.

Scientific reports·2019
Same author

A project of advanced solid-state neutron polarizer for PF1B instrument at Institut Laue-Langevin.

The Review of scientific instruments·2019
Same author

Uniaxial pressure setup for piezoresistance and magnetoresistance measurements in Heusler materials.

The Review of scientific instruments·2013
Same author

Spontaneous obesity-linked type 2 diabetes in the absence of islet amyloid in a cynomolgus monkey infected with bovine spongiform encephalopathy.

Veterinary pathology·2013
Same author

[Oral candidiasis and dentures].

Revue de stomatologie et de chirurgie maxillo-faciale·2010

Area of Science:

  • Gastroenterology
  • Immunology
  • Endocrinology

Background:

  • Intestinal dysfunction and gut immune dysregulation are implicated in type 1 diabetes pathogenesis.
  • The BB rat is a valuable animal model for studying spontaneous immune-mediated type 1 diabetes.

Purpose of the Study:

  • To review gut damage and dysfunction in BB rats concerning type 1 diabetes.
  • To emphasize the role of diet in diabetes incidence and identify diabetes-related wheat proteins.
  • To document immune system anomalies in gut-associated lymphoid tissues and pancreatic lymph nodes.

Main Methods:

  • Histological examination of gut damage.
  • Assessment of intestinal disaccharidase and peroxidase activity.
  • Analysis of glucagon-like peptide 1 levels, intestinal permeability, and mucin content.

Related Experiment Videos

  • Comparison of findings between diabetes-promoting and diabetes-retardant diets.

    • Main Results:

    • BB rats exhibit histological gut damage and altered intestinal enzyme activities.
    • Changes in gut permeability, mucin content, and GLP-1 levels are observed.
    • Diet composition influences diabetes incidence, with specific wheat proteins identified as potentially diabetogenic.
    • Immune cell anomalies are present in Peyer's patches, mesenteric lymph nodes, and pancreatic lymph nodes.

    Conclusions:

    • Diet plays a critical role in modulating type 1 diabetes development in BB rats.
    • Gut barrier function and immune homeostasis are significantly disrupted in diabetes-prone BB rats.
    • Further research into dietary interventions and gut-immune interactions is warranted for type 1 diabetes prevention and treatment.