Related Experiment Video
Updated: Aug 21, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Vascular access results from the Dialysis Outcomes and Practice Patterns Study (DOPPS): performance against Kidney
Hugh C Rayner1, Anatole Besarab, Wendy W Brown
1Birmingham Heartlands Hospital, United Kingdom.
Insights
Native arteriovenous (AV) fistulae are recommended for hemodialysis vascular access. However, AV fistula use varies globally, with the US lagging behind Europe and Japan, and catheter use is concerningly increasing.
Area of Science:
- Nephrology
- Vascular Surgery
- Public Health
Background:
- Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines advocate for native arteriovenous (AV) fistulae over grafts or catheters for hemodialysis.
- Guidelines recommend a maturation period of at least one month before AV fistula cannulation.
Purpose of the Study:
- To examine international vascular access practice patterns and guideline adherence using the Dialysis Outcomes and Practice Patterns Study (DOPPS).
- To investigate the association between vascular access choices and mortality risk in hemodialysis patients.
Main Methods:
- Analysis of data from the Dialysis Outcomes and Practice Patterns Study (DOPPS), an international research initiative.
- Comparison of vascular access modalities (AV fistula, AV graft, tunneled catheter) and their associated outcomes across different countries.
Main Results:
- Significant international variation exists in AV fistula utilization; Europe and Japan predominantly use fistulae, while the US uses more grafts.
- Patients receiving pre-dialysis care for over 30 days show higher rates of AV fistula initiation.
- Tunneled catheters are associated with increased mortality and subsequent fistula failure, with their use increasing globally.
- US dialysis facilities show longer fistula maturation times but worse fistula survival compared to European centers.
Conclusions:
- DOPPS data indicate disparities in practice patterns and guideline adherence across countries.
- Continued monitoring by DOPPS is essential to assess if improved guideline application can reduce access complications and enhance hemodialysis patient longevity.
Background:
The Kidney Disease Outcomes Quality Initiative Guidelines for Vascular Access in hemodialysis patients recommend native arteriovenous (AV) fistulae over AV grafts or catheters for permanent vascular access. They recommend letting fistulae mature > or =1 month before cannulation.
Methods:
The Dialysis Outcomes and Practice Patterns Study (DOPPS) provides an unparalleled means to examine vascular access practice patterns and guidelines internationally, with particular attention to associations with mortality risk.
Results:
Most patients in Europe and Japan dialyze through AV fistulae and very few use AV grafts; in the United States, more patients use grafts than fistulae. Patients who receive nephrologic care for over 30 days before starting dialysis have significantly higher chances of commencing via AV fistula. Medical directors of dialysis facilities in the United States commonly prefer grafts; in Europe and Japan, most prefer fistulae. In the United States, there is a relatively long average time between fistula creation and cannulation but significantly worse fistula survival than that seen in Europe. Tunneled catheters pose a higher mortality risk than permanent accesses and are associated with increased risk of failure of a subsequent fistula. The percentage of prevalent patients in the DOPPS countries using catheters has increased in recent years. DOPPS data suggest that performance in some countries falls short of practices achieved in other countries. AV fistula use is low in the United States but has been improving. The trend of increasing use of catheters in most countries is discouraging.
Conclusion:
The DOPPS will continue to monitor practice trends and explore whether greater application of guidelines will lead to fewer access complications and improved longevity for hemodialysis patients.
Related Concept Videos
Hemodialysis I: Introduction
Hemodialysis II: Procedure and Complications
Hemodialysis III: Nursing Management
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis
Acute Kidney Injury V: Interprofessional Care