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Newly observed binding mode in pancreatic ribonuclease
C F Aguilar1, P J Thomas, A Mills
1Crystallography Department, Birkbeck College, University of London, U.K.
Journal of Molecular Biology
|March 5, 1992
Abstract:
Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.