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Updated: Aug 21, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
Left atrial mass: thrombus mimicking myxoma
1Department of Internal Medicine, Marshfield Clinic, Marshfield, Wisconsin 54449, USA.
Insights
A large left atrial mass in a patient with atrial fibrillation was initially difficult to diagnose. Surgical resection revealed an organized thrombus, highlighting diagnostic challenges.
Area of Science:
- Cardiology
- Cardiac Surgery
- Pathology
Background:
- Left atrial masses can present diagnostic challenges, particularly in patients with atrial fibrillation.
- Distinguishing between cardiac tumors (e.g., myxoma) and thrombi based solely on imaging can be difficult.
Observation:
- A 31-year-old woman with paroxysmal atrial fibrillation presented with a large left atrial mass detected via echocardiography.
- Imaging revealed a 3 cm x 3 cm circular mass with smooth contours, exhibiting mobility that complicated differential diagnosis.
- The patient was on chronic anticoagulation therapy with coumadin.
Findings:
- Surgical resection of the intracardiac mass was performed.
- Pathologic examination confirmed the mass to be an organized thrombus.
- The case highlights the difficulty in differentiating left atrial thrombus from myxoma based on imaging characteristics.
Implications:
- This case underscores the importance of considering organized thrombus in the differential diagnosis of left atrial masses, even in anticoagulated patients.
- Accurate diagnosis is crucial for appropriate management and surgical planning.
- Further literature review is presented to aid in the differential diagnosis of such masses.
Abstract:
A 31-year-old woman underwent elective transthoracic echocardiography for paroxysmal atrial fibrillation, which showed a large left atrial mass. A two-dimensional echocardiogram showed a large left atrium mass. Subsequent transesophageal echocardiography showed a 3 cm x 3 cm circular mass with smooth contours. The differential diagnosis included myxoma versus thrombus, but because of morphology and mobility of the mass, it was difficult to differentiate one from the other. The patient had been on chronic coumadin therapy for paroxysmal atrial fibrillation. An operation was performed and the intracardiac mass resected. On pathologic examination the mass was diagnosed as an organized thrombus. A brief review of the literature has been presented to discuss the differential diagnosis of the mass in the left atrium.
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