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Baseline risk factors for the development of primary open-angle glaucoma in the Ocular Hypertension Treatment Study
Anne L Coleman1, Mae O Gordon, Julia A Beiser
1Jules Stein Eye Institute, University of California, Los Angeles, USA.
Purpose:
Higher baseline pattern standard deviation (PSD) and larger vertical cup-to-disk ratio (VC/D) were factors in the predictive model for the development of primary open-angle glaucoma (POAG) in the Ocular Hypertension Treatment Study. Because early changes in PSD and VC/D may be indicative of early POAG damage, we repeated the prediction model excluding PSD and VC/D.
Design:
Reanalysis of baseline factors for the development of POAG.
Methods:
We compared the hazard ratios for baseline factors predictive of POAG in the multivariate Cox proportional hazards model that included PSD and VC/D and in the model that excluded them.
Results:
Hazard ratios for baseline factors predictive of POAG in Ocular Hypertension Treatment Study were not substantially affected by the inclusion or exclusion of PSD and VC/D in the proportional hazards model.
Conclusion:
Whether PSD or VC/D was included in the Cox proportional hazards model, the same baseline factors were statistically significant and their hazard ratios were essentially similar.
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