Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diastolic dysfunction: can it be diagnosed by Doppler echocardiography?

Mathew S Maurer1, Daniel Spevack, Daniel Burkhoff

  • 1Department of Medicine, College of Physicians and Surgeons, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

Journal of the American College of Cardiology
|October 19, 2004
PubMed
Summary

Heart failure with normal ejection fraction (HFNEF) is common in older women and linked to diastolic dysfunction. This study distinguishes Doppler measures from true ventricular diastolic function, questioning HFNEF

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Right Ventricular Metrics as End Points in Clinical Trials: A Review.

JAMA cardiology·2026
Same author

Comprehensive clinical benefit of CCM in HFrEF patients: a win-ratio analysis of FIX-HF-5C randomized trial.

ESC heart failure·2026
Same author

Universal Pulmonary Resistance-Compliance Relationship: And Why It Matters?

Circulation. Heart failure·2026
Same author

De Novo Aortic Insufficiency and Its Progression in Patients on Microaxial Flow Pump Support Before Durable Left Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions.

Heart failure reviews·2026
Same author

Does Pacemaker Mode Affect Outcomes in Patients With HeartMate 3 LVAD?

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026

Area of Science:

  • Cardiology
  • Physiology

Background:

  • Heart failure with normal ejection fraction (HFNEF) predominantly affects older women.
  • It is often attributed to diastolic dysfunction.
  • Doppler echocardiography is the standard diagnostic tool for diastolic function.

Purpose of the Study:

  • To differentiate Doppler-derived measures of ventricular filling from intrinsic ventricular diastolic properties.
  • To compare Doppler echocardiography with pressure-volume analysis for assessing diastolic function.
  • To question the universal pathophysiologic mechanisms in HFNEF.

Main Methods:

  • Physiologic measures of intrinsic ventricular diastolic function were determined using pressure-volume analysis.
  • These measures were compared with those derived from Doppler echocardiography.

Related Experiment Videos

Main Results:

  • Doppler-derived indexes of ventricular filling do not specifically reflect intrinsic passive diastolic properties.
  • Abnormal filling dynamics do not necessarily indicate intrinsic myocardial diastolic dysfunction.

Conclusions:

  • A fundamental question is raised regarding the unifying pathophysiologic mechanisms in HFNEF.
  • Delayed relaxation and/or stiffened passive properties may not be universally present in all HFNEF patients.