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Related Experiment Videos

Strain echocardiography tracks dobutamine-induced decrease in regional myocardial perfusion in nonocclusive coronary

Gabriel Yip1, Bijoy Khandheria, Marek Belohlavek

  • 1Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Journal of the American College of Cardiology
|October 19, 2004
PubMed
Summary

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Strain echocardiography parameters, including systolic strain rate (sSR) and time to regional lengthening (T(RL)), accurately predict changes in regional myocardial perfusion (RMBF) during dobutamine stress. These novel quantitative strain parameters show promise for improving ischemia detection in stress echocardiography.

Area of Science:

  • Cardiology
  • Echocardiography
  • Myocardial Perfusion Imaging

Background:

  • Strain echocardiography assesses regional myocardial mechanical activity.
  • Ischemia impairs systolic strain rate (sSR) and prolongs time to regional lengthening (T(RL)).
  • Dobutamine stress echocardiography is a key tool for diagnosing myocardial ischemia.

Purpose of the Study:

  • To evaluate if strain echocardiography parameters correlate with regional myocardial perfusion (RMBF) changes during dobutamine stress.
  • To assess the diagnostic accuracy of sSR and T(RL) for detecting ischemia.

Main Methods:

  • A closed-chest pig model with induced coronary stenosis was used (n=14).
  • Regional myocardial blood flow (RMBF) was measured using colored microspheres.

Related Experiment Videos

  • Strain parameters (sSR, T(RL)) and hemodynamics were assessed at baseline and during dobutamine infusion, with and without stenosis.

    • Main Results:

    • Peak sSR demonstrated a strong correlation with RMBF (r=0.70).
    • Dobutamine increased RMBF and sSR while decreasing T(RL) in normal segments; this was blunted with stenosis.
    • sSR achieved 81% sensitivity and 91% specificity for predicting reduced RMBF, while T(RL) showed 65% sensitivity and 91% specificity.

    Conclusions:

    • Novel strain parameters accurately predict regional myocardial perfusion changes during dobutamine stress.
    • Quantitative strain echocardiography may enhance current ischemia detection methods.
    • These findings suggest improved accuracy and reproducibility for stress echocardiography.