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Related Experiment Video

Updated: Jun 25, 2026

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

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Published on: September 11, 2012

Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344

Yumi Shimoji¹, Hiroyuki Kohno, Kumiko Nanda

¹Research Center, Tamanoi Vinegar, Co., Ltd., Nara, Japan.

Nutrition and Cancer

|October 19, 2004

Summary

Ethyl acetate extract of Kurosu (EK), a rice vinegar, inhibited colon cancer development in rats. This study suggests EK may be effective in preventing colon carcinogenesis.

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Area of Science:

Biomedical Science
Cancer Research
Nutritional Science

Background:

Colon cancer is a significant health concern.
Azoxymethane (AOM) is a chemical carcinogen used to induce colon cancer in research models.
Kurosu (EK), a vinegar from unpolished rice, has potential health benefits.

Purpose of the Study:

To investigate the effects of ethyl acetate extract of Kurosu (EK) on azoxymethane (AOM)-induced colon carcinogenesis in rats.
To determine if EK administration can inhibit the development of colon adenocarcinoma.

Main Methods:

Male F344 rats were used in the study.
Azoxymethane (AOM) was administered to induce colon cancer.
Rats received drinking water with varying concentrations of EK (0%, 0.05%, 0.1%) for 35 weeks.

Main Results:

EK administration significantly reduced the incidence of colon adenocarcinoma.
EK significantly inhibited the multiplicity of colon adenocarcinoma.
A statistically significant difference (P < 0.05) was observed compared to the AOM-alone group.

Conclusions:

Ethyl acetate extract of Kurosu (EK) demonstrates inhibitory effects on colon carcinogenesis.
EK may be a potential chemopreventive agent for colon cancer.