Increased stability of bmr3 mRNA results in a multidrug-resistant phenotype in Bacillus subtilis
1Department of Molecular Biology, School of Health Sciences, Kyorin University, 476 Miyashita, Hachioji, Tokyo 192-0005, Japan. ohkir@kyorin-u.ac.jp
Journal of Bacteriology
|October 19, 2004
Abstract:
A spontaneous mutant isolated in the presence of a high concentration of puromycin acquired a multidrug-resistant phenotype. Expression of the bmr3 gene was dramatically increased. A base substitution, T to A at the +4 position, detected in the mutant resulted in the stabilization of bmr3 mRNA.
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