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Respiratory findings in pharmaceutical workers.

Eugenija Zuskin1, Jadranka Mustajbegovic, E Neil Schachter

  • 1Andrija Stampar School of Public Health, Zagreb, Croatia.

American Journal of Industrial Medicine
|October 19, 2004
PubMed
Summary

Pharmaceutical workers face increased respiratory risks, including chronic symptoms and impaired lung function, particularly those with longer tenure and smokers. This highlights the need for workplace safety measures in the pharmaceutical industry.

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Area of Science:

  • Occupational Health
  • Pulmonology
  • Environmental Medicine

Background:

  • Pharmaceutical industry work environments may pose risks for respiratory health.
  • Previous studies suggest potential links between pharmaceutical work and respiratory issues.

Purpose of the Study:

  • To investigate respiratory health risks in pharmaceutical workers.
  • To characterize the prevalence of chronic and acute respiratory symptoms.
  • To assess ventilatory capacity and identify risk factors.

Main Methods:

  • Study included 163 female and 35 male pharmaceutical workers and 113 controls from a food packing facility.
  • Chronic respiratory symptoms assessed using the British Medical Research Council questionnaire.
  • Ventilatory capacity measured via maximum expiratory flow-volume (MEFV) curves (FVC, FEV1, FEF50, FEF25).

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Main Results:

  • Pharmaceutical workers showed a higher prevalence of chronic symptoms (sinusitis, nasal catarrh, dyspnea) and acute workshift symptoms.
  • Smoking and longer employment duration in the pharmaceutical industry were significant risk factors, especially for men.
  • Pulmonary function tests revealed significantly decreased values (P < 0.01), particularly for FEF50 and FEF25, indicating small airway obstruction.

Conclusions:

  • Workers in the pharmaceutical industry are susceptible to developing respiratory symptoms.
  • Ventilatory impairment, suggestive of obstructive changes in smaller airways, is associated with pharmaceutical work.
  • Findings underscore the occupational health risks within the pharmaceutical sector.