Related Experiment Video

Updated: Aug 21, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Pulmonary arterial pressure in children with allergic rhinitis

Ismail Reisli1, Bulent Oran, Osman Baspinar

  • 1Department of Pediatrics, Meram Medical Faculty, University of Selcuk, Konya, Turkey.

American Journal of Rhinology
|October 20, 2004
PubMed

Insights

Children with allergic rhinitis have elevated pulmonary arterial pressure. Nasal corticosteroid treatment effectively reduced this pressure, highlighting a reversible link between nasal blockage and heart health.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Cardiovascular Health

Background:

  • Chronic upper airway obstruction in children can elevate pulmonary arterial pressure.
  • Allergic rhinitis, a common cause of nasal blockage, is linked to this obstruction.
  • Understanding this connection is crucial for pediatric cardiovascular health.

Purpose of the Study:

  • To assess pulmonary arterial pressures in children with allergic rhinitis.
  • To investigate the impact of topical corticosteroid therapy on these pressures.
  • To explore the reversibility of elevated pulmonary arterial pressure.

Main Methods:

  • Doppler echocardiography used to measure pulmonary arterial pressures.
  • Study included 49 children with seasonal (27) and perennial (22) allergic rhinitis.
  • Mometasone furoate (100 microg/day) administered for 8 weeks.

Main Results:

  • Children with allergic rhinitis showed significantly higher pulmonary arterial systolic, mean, and diastolic pressures than controls.
  • Treatment with mometasone furoate led to significant reductions in systolic and mean pulmonary arterial pressures.
  • Diastolic pressure reduction was not statistically significant post-treatment.

Conclusions:

  • Allergic rhinitis is associated with increased pulmonary arterial pressure in children.
  • Nasal topical corticosteroids can reverse elevated pulmonary arterial pressure caused by allergic rhinitis.
  • Further research is needed to clarify the clinical implications of this finding.
Abstract

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Pressure Relationships in Thoracic Cavity01:24

Pressure Relationships in Thoracic Cavity

Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...