Optical coherence tomography of subfoveal choroidal neovascularization treated with transpupillary thermotherapy

Transpupillary thermotherapy (TTT) has been proposed as a new treatment modality for choroidal neovascularization (CNV). Most studies conducted show decreased exudation due to CNV and reduction of subretinal elevation. Optical coherence tomography (OCT) shows a dynamic sequence of changes early after treatment. Within 1 hour after TTT, OCT shows increased retinal thickness and intraretinal fluid with retinal elevation. One week after treatment, OCT shows decreased subretinal and intraretinal fluid and diminished retinal elevation. OCT can be a valuable method to assess the early effect of TTT. A placebo-controlled, multi-center trial (TTT4CNV) evaluating the long-term efficacy and visual implications of TTT in occult CNV is underway.