Related Experiment Videos
Ocular surface disorders and tear function changes in patients with chronic renal failure
Murat Ozdemir1, Sevgi Bakaris, Gokhan Ozdemir
1Department of Ophthalmology, School of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. drmozdemir@hotmail.com
Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|October 20, 2004
Summary
Patients with chronic kidney disease on hemodialysis show significant ocular surface changes, including squamous metaplasia and impaired tear function. Abnormal rose bengal staining and subjective complaints can monitor these eye conditions.
Area of Science:
- Ophthalmology
- Nephrology
- Surface Science
Background:
- Patients with chronic renal failure (CRF) undergoing hemodialysis may develop ocular surface issues like conjunctival squamous metaplasia and calcification.
- The relationship between these ocular changes and impaired tear function in CRF patients is not fully understood.
Purpose of the Study:
- To investigate the association between ocular surface disorders and tear function alterations in patients with CRF undergoing hemodialysis.
Main Methods:
- A case-control study involving 42 CRF patients and 20 controls.
- Ophthalmologic examinations, tear function tests (Schirmer's, tear film break-up time [BUT]), rose bengal staining, and impression cytology were performed.
- Corneoconjunctival calcification and conjunctival squamous metaplasia were graded, and subjective ocular complaints were recorded.
Main Results:
- CRF patients exhibited significantly higher grades of squamous metaplasia (p < 0.001) and corneoconjunctival calcification (p = 0.022) compared to controls.
- Abnormal tear film BUT (p = 0.002) and rose bengal staining (p = 0.023) were more frequent in CRF patients.
- Squamous metaplasia correlated with abnormal rose bengal staining (p < 0.001) and subjective ocular complaints (p = 0.026).
Conclusions:
- Abnormal rose bengal staining and subjective ocular complaints serve as valuable follow-up indicators for ocular surface disorders in hemodialysis patients.
- These findings highlight the need for regular ophthalmic monitoring in patients with chronic renal failure.