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Updated: Aug 21, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
The influence of obstructive sleep apnea on FFR measurements for coronary lesion assessment
Jeffrey P Ciaramita1, Walter A Parham, Steven Herrmann
1J. Gerard Mudd Cardiac Catheterization Laboratory, St. Louis University Health Sciences Center, 3635 Vista Avenue at Grand Boulevard, St. Louis, MO 63110, USA.
Abstract:
Fractional flow reserve (FFR) determinations have been demonstrated to be largely independent of changes in systemic hemodynamic changes. Herein, we describe a case of obstructive sleep apnea cyclically altering FFR measurements from normal to abnormal in a patient with an intermediately severe coronary narrowing following treatment for an acute coronary syndrome. To eliminate uncertainty, FFR measurements should be made if possible during suspended respiration.
