Related Experiment Video
Updated: Aug 15, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
The future incidence of cutaneous melanoma within the UK
1Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK. b.l.diffey@ncl.ac.uk
Background:
The incidence of cutaneous malignant melanoma continues to rise in the U.K., where since the 1970s malignant melanoma has seen the largest increase in incidence rates compared with other major cancers. To counteract this rise, sun awareness campaigns have been introduced in this and several other countries since the 1980s with the object of encouraging people to limit their exposure to strong sunshine and to avoid sunburn in the expectation that these interventions will act favourably on skin cancer incidence.
Objectives:
To predict the incidence of cutaneous malignant melanoma in the British population over the next half-century as a consequence of either a stabilization or a reduction in lifetime risk of melanoma for recent and future birth cohorts so that cancer services can be planned appropriately over the coming years.
Methods:
An age-cohort model has been developed that estimates future incidence rates of melanoma in the U.K.
Results:
The results suggest that the benefits of intervention strategies, assuming that these will translate eventually into a downturn in melanoma incidence, may not be seen for another 30 years or so, by which time the predicted age-standardized rate of melanoma may be around twice that presently observed.
Conclusions:
Prevention of deaths from melanoma depends on both reducing incidence and achieving earlier diagnosis. This analysis has indicated that the former is unlikely to be realized in the U.K. for some decades, and so early detection of suspected lesions, with prompt surgery to remove confirmed tumours, is paramount if mortality from melanoma is to be kept in check.
Related Concept Videos
Cancer Prevention
Some...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection

