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Medical treatment of missed abortion using misoprostol
N T N Ngoc1, J Blum, E Westheimer
1Hung Vuong Hospital, Ho Chi Minh City, Vietnam.
Objective:
To compare the efficacy of two routes of misoprostol administration (oral and vaginal) for treatment of missed abortion.
Methods:
Two hundred women with confirmed missed abortion received 800 mcg misoprostol either orally or vaginally. All women returned for follow-up care 2 days later. If the pregnancy was not completely evacuated at this time, women could wait an additional 5 days or undergo immediate surgical completion. Efficacy was defined as the percent of women discharged from the study without need for surgical intervention.
Results:
Efficacy was high in both groups and not statistically different (oral=89.0%, vaginal=92.9%). While the groups did not differ in terms of the completion rate by day 2 (oral=41.6%, vaginal=52.7%), the mean time to expulsion was longer (21.04 h) in the oral group than the vaginal group (13.47 h), p=0.041. Women in both groups were highly satisfied with the method.
Conclusions:
Medical management of missed abortion with either oral or vaginal misoprostol is highly effective and highly acceptable.
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