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Updated: Aug 21, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Role of sirtuin proteins in life extension by caloric restriction
1Department of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio 78229-3900, USA. masoro@aol.com
Abstract:
The deacetylase activity of sirtuin proteins may play a key role in the life extending action of caloric restriction in organisms ranging from yeast to mammals. Recent research has been focused on the possible afferent pathway by which caloric restriction increases the deacetylase activity and on the efferent pathway by which the increased deacetylase activity extends life. Further research is needed to firmly establish the role of sirtuin proteins in life extension by caloric restriction in mammals.
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