Related Experiment Video
Updated: Aug 21, 2026

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Early effects of Helicobacter pylori infection in patients undergoing bariatric surgery
Archana Ramaswamy1, Edward Lin, Bruce J Ramshaw
1Department of Surgery, Section of Gastrointestinal Surgery, Emory Bariatrics, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Hypothesis:
Following weight loss surgery, many patients initially experience nonspecific foregut symptoms. Helicobacter pylori infection of the gastric remnant may be associated with foregut symptoms.
Design:
Inception cohort.
Setting:
University hospital.
Patients:
Ninety-nine consecutive patients being evaluated for weight loss surgery.
Intervention:
All patients underwent preoperative esophagogastroduodenoscopy and H pylori testing.
Main Outcome Measures:
Foregut symptoms were documented at routine post-weight loss surgery follow-up visits.
Results:
Preoperatively, 24% of patients tested positive for H pylori. Postoperative foregut symptoms were significant in 48% of the H pylori-positive group, and 19% of the H pylori-negative group (P = .02). This increase remained even after controlling for age, sex, preoperative presence of antritis, type of surgery performed, and body mass index (odds ratio, 3.6; 95% confidence interval,1.1-11.8). Patients with prolonged symptoms who tested positive for H pylori were given an eradication treatment.
Conclusions:
The prevalence of H pylori infection in patients undergoing weight loss surgery is high, and a significant proportion of them have postoperative foregut symptoms. Consideration should be given to H pylori treatment in these patients.
Related Concept Videos
Gastritis II: Pathophysiology
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
Peptic Ulcer
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Peptic Ulcer Disease II: Pathophysiology
