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Two cases of multiple eccrine spiradenoma with linear or localized formation
Aki Yoshida1, Toshiki Sato, Yuki Sugawara
1Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.
The Journal of Dermatology
|October 20, 2004
Summary
Two rare cases of recurrent, multiple eccrine spiradenoma, presenting as extensive lesions, highlight the varied clinical and histological features of this rare skin tumor. Surgical excision was effective for both patients.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Eccrine spiradenoma is a benign adnexal neoplasm originating from eccrine sweat glands.
- Recurrent and multiple presentations are uncommon, with linear/zosteriform/nevoid patterns being exceptionally rare.
Observation:
- Two distinct cases of recurrent, multiple eccrine spiradenoma are presented: a 30-year-old woman with linear lesions on the chin and neck, and a 57-year-old woman with grouped lesions in the occipital region.
- Lesions varied from multiple red papules to soft blue-red nodules, with pain reported in one case.
- Literature review identified only 15 previously reported cases with similar linear/zosteriform/nevoid patterns.
Findings:
- Histological examination of papules revealed typical features with two cell types: large clear cells and small dark cells.
- Cystic tumors showed variable histology, including homogeneous eosinophilic material in one case and abundant interstitial tissue in the other.
- Both patients underwent successful surgical excision of the affected lesions.
Implications:
- These cases expand the understanding of the clinical spectrum and histological variations of multiple eccrine spiradenoma.
- The findings underscore the importance of considering rare presentations of eccrine spiradenoma in clinical diagnosis and management.
- Further research into the pathogenesis of recurrent and multiple eccrine spiradenoma may inform future treatment strategies.