Related Experiment Video
Updated: Aug 21, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Outcome after treatment of high-grade squamous intraepithelial lesions: relation between colposcopically directed
E F C Murta1, R Conti, J Rodovalho
1Discipline of Gynaecology and Obstetrics, Faculty of Medicine of Triângulo Mineiro, Uberaba M.G. (Brazil).
Purpose Of Investigation:
The hypothesis that cold-knife conization performed in women with high-grade squamous intraepithelial lesions (HSIL) and unsatisfactory colposcopy is a better procedure than the loop electrosurgical procedure (LEEP) is tested.
Methods:
A retrospective study was conducted in conization specimens of women submitted to LEEP (n = 102) or conization (n = 245) due to HSIL. Age, biopsy, compromised surgical margins in conization, and recurrence were analysed.
Results:
The frequency of invasion, non-compromised margins, and recurrence in conization and LEEP were, respectively, 7.7% versus 2.9%, 64.1% versus 48% (p = 0.008), and 33.8% versus 24.1%. Eight (42.1%) and five (26.3%) of 19 women submitted to conization where invasion was found in surgical specimens were, respectively, menopausal or had unsatisfactory colposcopy. Twenty-five (96.2%) of 26 and 23 (95.8%) of 24, respectively, undergoing conization and LEEP had recurrence in the first five years.
Conclusion:
We recommend the use of cold-knife conization in cases where the lesion is located deep in the cervical canal.
