Related Experiment Video
Updated: Mar 9, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
[Allergy to cosmetics. II. Preservatives]
Marta Kieć-Swierczyńska1, Beata Krecisz, Dominika Swierczyńska-Machura
1Przychodni Chorób Zawodowych, Instytutu Medycyny Pracy im. prof. J. Nofera w Lodzi.
Abstract:
Disinfectants are essential components of body care preparations, household goods and industrial products. They inhibit growth of bacteria and fungi. Esters of parahydroxybenzoate acid and products that release small amounts of formaldehyde (Germal 115, Germal II, Dovicil 200, Bronopol, DMDM hydantoine) were most frequently used in the past. In the 1980s, Katon CG (5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one) evoked the epidemics of contact dermatitis in Sweden, Finland, Germany, Italy and The Netherlands. In the next years, allergy to another preservative, Euxyl K 400 was dramatically growing. Studies carried out in 11 European countries showed that hypersensitivity increased from 0.7% in 1991 to 3.5% in 2000. It was revealed that not only cosmetics left on the skin sensitize, but also those washable. Apart from preservatives, allergic reactions are induced by emulgators, antioxidants, moisteners, lubricants, stabilizers and stickers.
More Related Videos
08:29Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics
Published on: November 27, 2017
10:13Eye Irritation Test EIT for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial RhCE Tissue Model
Published on: August 23, 2015
Related Concept Videos
Drug Toxicity: Allergic Reactions
Allergic Reactions: Anaphylaxis
Allergic Reactions
Allergic Drug Reactions
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...