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Allergic fungal sinusitis.

J P Corey1

  • 1University of Chicago, Pritzker School of Medicine, Illinois.

Otolaryngologic Clinics of North America
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Allergic Fungal Sinusitis (AFS) affects young adults with difficult-to-treat sinus infections. Diagnosis involves identifying allergic mucin and eosinophils, with treatment including surgical drainage and corticosteroids.

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Area of Science:

  • Otolaryngology
  • Allergy and Immunology

Background:

  • Allergic Fungal Sinusitis (AFS) is an emerging diagnosis.
  • It presents in young adults with chronic rhinosinusitis resistant to standard treatments.

Purpose of the Study:

  • To describe the clinical presentation, diagnostic findings, and treatment of Allergic Fungal Sinusitis.

Main Methods:

  • Review of radiologic findings (CT scans) showing sinus opacification or calcifications.
  • Laboratory tests revealing elevated total IgE, peripheral eosinophilia, and positive fungal skin tests.
  • Histopathological examination of surgical sinus drainage identifying allergic mucin, eosinophils, Charcot-Leyden crystals, and fungal hyphae.

Main Results:

  • Patients exhibit characteristic allergic responses to fungi.

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  • Radiology may show sinus abnormalities.
  • Histology confirms allergic mucin and eosinophilic inflammation without tissue invasion.

    • Conclusions:

    • AFS is a distinct entity characterized by allergic mucin and eosinophilic inflammation.
    • Surgical sinus drainage is both diagnostic and therapeutic.
    • Systemic corticosteroids are crucial for preventing disease recurrence.